Our research has the overall theme of understanding genomic variants associated with common complex inflammatory diseases by using a tremendous amount of genomic, transcriptomic, epigenetic, and metagenomic data from cutting edge technologies like next-generation sequencing and microarray. Human genetic studies into common complex diseases have uncovered a number of genetic loci associated with disease susceptibility, highlighting HLA variants and many other variants in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging publicly available multi-omics data, actual patients' omics data, and computational approaches are enabling us to use genetic variants to understand disease genes, functionally relevant cell types, and biological pathways that are involved in impaired immune processes and disease phenotypes, suggesting drug targets and potentially repurposable drugs.