Our research has the overall theme of understanding genomic variants associated with common complex inflammatory diseases by using a tremendous amount of genomic, transcriptomic, epigenetic, and metagenomic data from cutting edge technologies like next-generation sequencing and microarray. Human genetic studies into common complex diseases have uncovered a number of genetic loci associated with disease susceptibility, highlighting HLA variants and many other variants in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging publicly available multi-omics data, actual patients' omics data, and computational approaches are enabling us to use genetic variants to understand disease genes, functionally relevant cell types, and biological pathways that are involved in impaired immune processes and disease phenotypes, suggesting drug targets and potentially repurposable drugs.
News
-
Chae-Yeon's paper on a new MHC imputation reference panel and HLA/C4 variant analysis in SLE was accepted for publication in Annals of the Rheumatic Diseases (IF=20.3) on June 6, 2025.
-
The DDX6-CXCR5 functional variant study in lupus and Sjögren’s disease, coauthored by Kwangwoo, was published online in Annals of the Rheumatic Diseases (IF = 20.3) on May 29, 2025.
-
KimLab members and Prof. Sang-Cheol Bae (Hanyang University) visited Beijing for collaborative genetic research from May 25 to 28, 2025.
-
Sehwan's paper on the genetics of preclinical autoimmune conditions was accepted for publication in Annals of the Rheumatic Diseases (IF=20.3) on December 5, 2024.
-
Junho's paper on gut bacteria and human genetic variants associated with comorbid mental disorders in IBD was accepted for publication in npj Genomic Medicine on October 5, 2024.
-
Junho's co-first authored paper on upper respiratory mucosa microbiota in rheumatoid arthritis was published in PLoS One on August 6, 2024.
-
Ayeong and Hyunmin visited Beijing and Nanjing for collaborative genetic research from May 13 to 18, 2024.
THE LATEST PUBLICATIONS
Genetic burden of lupus increases the risk of transition from normal to preclinical autoimmune conditions via antinuclear antibody development
Sehwan Chun^, So-Young Bang^, Ayeong Kwon, Chan Young Kim, Soojin Cha, Young-Chang Kwon, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Ji-Young Han, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*
Annals of the Rheumatic Diseases. 2025 Jan 29. S0003-4967(25)00069-X.
doi: 10.1016/j.ard.2025.01.015.doi:
Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders
Junho Lee^, Shin Ju Oh^, Eunji Ha, Ga Young Shin, Hyo Jong Kim, Kwangwoo Kim*, Chang Kyun Lee*
npj Genomic Medicine. 2024 Oct 29;9,52.
doi: 10.1038/s41525-024-00440-w.
Associations of upper respiratory mucosa microbiota with rheumatoid arthritis, autoantibodies, and disease activity
Young Bin Joo^, Junho Lee^, Yune-Jung Park, So-Young Bang, Kwangwoo Kim*, Hye-Soon Lee*
PLoS One . 2024 Aug 6;19(8):e0308010.
doi: 10.1371/journal.pone.0308010.
Transcriptomic network analysis reveals key drivers of response to anti-TNF biologics in patients with rheumatoid arthritis
Chae-Yeon Yu, Hye-Soon Lee, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Sang-Cheol Bae, Kwangwoo Kim*, So-Young Bang*
Rheumatology (Oxford). 2024 May 2;63(5):1422-1431.
doi: 10.1093/rheumatology/kead403.