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Our research has the overall theme of understanding genomic variants associated with common complex inflammatory diseases by using a tremendous amount of genomic, transcriptomic, epigenetic, and metagenomic data from cutting edge technologies like next-generation sequencing and microarray. Human genetic studies into common complex diseases have uncovered a number of genetic loci associated with disease susceptibility, highlighting HLA variants and many other variants in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging publicly available multi-omics data, actual patients' omics data, and computational approaches are enabling us to use genetic variants to understand disease genes, functionally relevant cell types, and biological pathways that are involved in impaired immune processes and disease phenotypes, suggesting drug targets and potentially repurposable drugs.

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News

  • Hyunmin joined the Kim lab as a PhD student in September 2023. Welcome!

  • A two-year collaborative research with Prof. Cui in Beijing was awarded a grant from NRF-NSFC in Aug 2023.

  • A GWAS on Crohn's disease was published online in Journal of Crohn's and Colitis (IF=8.0) on July 31, 2023.

  • Chae-Yeon's transcriptomics analysis paper was accepted for publication in Rheumatology (IF=5.5) on July 28, 2023.

  • Sehwan received the Young Scientist Award from LUPUS & KCR 2023 in May 2023.

  • Lupus PRS study by Eunji was published in Arthritis & Rheumatology (IF=15.483) in April 2023.

  • Junho and Sehwan started the PhD program at the Kim lab, and Eunji departed for the US for her postdoc training at UPenn in March 2023.

  • Eunji received the Best Dissertation Award from the president of Kyung Hee University on her graduation day in Feb 2023.

  • Ayeong won the Young Scientist Award from the KOGO winter symposium in Feb 2023.

  • Ki Jung HWANG, Yujin CHO, and Hyunmin IM joined the lab as undergraduate researchers in Jan 2023.

THE LATEST PUBLICATIONS
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Transcriptomic network analysis reveals key drivers of response to anti-TNF biologics in patients with rheumatoid arthritis

Chae-Yeon Yu, Hye-Soon Lee, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Sang-Cheol Bae, Kwangwoo Kim*, So-Young Bang*

Rheumatology. accepted for publication.

doi: 

Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn's Disease and Interact with Regulatory Variants for TAP2

Kwangwoo Kim^*, Shin Ju Oh^, Junho Lee, Ayeong Kwon, Chae-Yeon Yu, Sangsoo Kim, Chang Hwan Choi, Sang-Bum Kang, Tae Oh Kim, Dong Il Park, Chang Kyun Lee*

Journal of Crohn's and Colitis. 2023 Jul 31. Online ahead of print.
doi: 10.1093/ecco-jcc/jjad127.

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Higher genetic risk loads confer more diverse manifestations and higher risk of lupus nephritis in systemic lupus erythematosus

Young-Chang Kwon^, Eunji Ha^, Hyuk-Hee Kwon, Dae Jin Park, Jung-Min Shin, Young Bin Joo, Won Tae Chung, Dae-Hyun Yoo, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*, So-Young Bang*

Arthritis Rheumatol. 2023 Apr 3. Online ahead of print.

doi: 10.1002/art.42516.

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