Our research has the overall theme of understanding genomic variants associated with common complex inflammatory diseases by using a tremendous amount of genomic, transcriptomic, epigenetic, and metagenomic data from cutting edge technologies like next-generation sequencing and microarray. Human genetic studies into common complex diseases have uncovered a number of genetic loci associated with disease susceptibility, highlighting HLA variants and many other variants in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging publicly available multi-omics data, actual patients' omics data, and computational approaches are enabling us to use genetic variants to understand disease genes, functionally relevant cell types, and biological pathways that are involved in impaired immune processes and disease phenotypes, suggesting drug targets and potentially repurposable drugs.
News
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Ayeong and Hyunmin attended EULAR 2025 held in Barcelona from June 11 to 14.
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Chae-Yeon's paper on a new MHC imputation reference panel and HLA/C4 variant analysis in SLE was accepted for publication in Annals of the Rheumatic Diseases (IF=20.6) on June 6, 2025.
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The DDX6-CXCR5 functional variant study in lupus and Sjögren’s disease, coauthored by Kwangwoo, was published online in Annals of the Rheumatic Diseases (IF = 20.6) on May 29, 2025.
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KimLab members and Prof. Sang-Cheol Bae (Hanyang University) visited Beijing for collaborative genetic research from May 25 to 28, 2025.
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Sehwan's paper on the genetics of preclinical autoimmune conditions was accepted for publication in Annals of the Rheumatic Diseases (IF=20.6) on December 5, 2024.
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Junho's paper on gut bacteria and human genetic variants associated with comorbid mental disorders in IBD was accepted for publication in npj Genomic Medicine on October 5, 2024.
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Junho's co-first authored paper on upper respiratory mucosa microbiota in rheumatoid arthritis was published in PLoS One on August 6, 2024.
THE LATEST PUBLICATIONS
Development of an MHC imputation panel highlights independent contributions of HLA amino acid residues and C4 copy number variations to SLE risk
Chae-Yeon Yu^, Dong Mun Shin^, Sung Min Kim, Yui Taek Lee, Sungwon Jeon, Sehwan Chun, So-Young Bang, Hye-Soon Lee, Xianyong Yin, Yong Cui, Xuejun Zhang, Jong Bhak, Soon Ji Yoo, Young Jin Kim*, Bong-Jo Kim*, Sang-Cheol Bae*, Kwangwoo Kim*.
Annals of the Rheumatic Diseases. in press
doi: https://doi.org/10.1016/j.ard.2025.06.2121 [July, 2025]
Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
Mandi M. Wiley, Marcin Radziszewski, Bhuwan Khatri, Michelle L. Joachims, Kandice L. Tessneer, Anna M. Stolarczyk, Songyuan Yao, James Li, Cherilyn Pritchett-Frazee, Audrey A. Johnston, Astrid Rasmussen, Juan-Manuel Anaya, Lara A. Aqrawi, Sang-Cheol Bae, Eva Baecklund, Albin Björk, Johan G. Brun, Sara Magnusson Bucher, Nick Dand, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d’Elia, Cecilia Fugmann, Stuart B. Glenn, Chen Gong, Jacques-Eric Gottenberg, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglænd Johnsen, Malin V. Jonsson, Jennifer A. Kelly, Sharmily Khanam, Kwangwoo Kim, Marika Kvarnström, Thomas Mandl, Javier Martín, David L. Morris, Gaetane Nocturne, Katrine Brække Norheim, Peter Olsson, Øyvind Palm, Jacques-Olivier Pers, Nelson L. Rhodus, Christopher Sjöwall, Kathrine Skarstein, Kimberly E. Taylor, Phil Tombleson, Gudny Ella Thorlacius, Swamy R. Venuturupalli, Edward M. Vital, Daniel J. Wallace, Lida Radfar, Michael T. Brennan, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Silke Appel, Per Eriksson, Simon J Bowman, Roald Omdal, Lars Rönnblom, Blake M. Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Caroline H Shiboski, Sjögren’s International Collaborative Clinical Alliance (SICCA), Marie Wahren-Herlenius, Marta E. Alarcón-Riquelme, PRECISESADS Clinical Consortium, Wan-Fai Ng, UK Primary Sjögren’s Syndrome Registry, Kathy L. Sivils, Joel M. Guthridge, Indra Adrianto, Timothy J. Vyse, Betty P. Tsao, Gunnel Nordmark, Christopher J. Lessard*.
Annals of the Rheumatic Diseases. in press
doi: https://doi.org/10.1016/j.ard.2025.04.023 [May, 2025]
Genetic burden of lupus increases the risk of transition from normal to preclinical autoimmune conditions via antinuclear antibody development
Sehwan Chun^, So-Young Bang^, Ayeong Kwon, Chan Young Kim, Soojin Cha, Young-Chang Kwon, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Ji-Young Han, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*
Annals of the Rheumatic Diseases. 2025 Jan 29. S0003-4967(25)00069-X.
doi: 10.1016/j.ard.2025.01.015.doi:
Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders
Junho Lee^, Shin Ju Oh^, Eunji Ha, Ga Young Shin, Hyo Jong Kim, Kwangwoo Kim*, Chang Kyun Lee*
npj Genomic Medicine. 2024 Oct 29;9,52.
doi: 10.1038/s41525-024-00440-w.